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Cat. No.	Product Name	Target	Signaling Pathways
T2584	Octreotide SMS 201-995,奥曲肽	Somatostatin	GPCR/G Protein
	Octreotide (SMS 201-995) 是一种有效的生长激素、胰高血糖素和胰岛素抑制剂。它主要与生长抑素 2、3 和 5 亚型受体结合，可增强 Gi 活性，降低胞内 cAMP 的产生。
TP2207	Pasireotide Acetate	Somatostatin	GPCR/G Protein
	Pasireotide acetate 是长效的环己肽生长激素抑制素类似物，具有抗分泌、抗增殖和促凋亡活性。它可抑制 GH、IGF-I 和 ACTH 的分泌，可用于研究肢端肥大症和库欣病。它还可以提高生长抑素受体的激动剂活性，对sst1、2、3、4、5的pKi 分别为 8.2、9.0、9.1、小于7.0 和 9.9。
T9692	Paltusotine	Somatostatin	GPCR/G Protein
	Paltusotine 是一种口服有效的，非肽选择性生长抑素 2 型受体激动剂。在长效生长抑素受体配体作用后，Paltusotine 仍可维持 GH 和 IGF-1 水平。
T4119	Octreotide Acetate 醋酸奥曲肽,SMS 201995,Longastatin,Sandostatin,SMS 201-995 (acetate)	Somatostatin	GPCR/G Protein
	Octreotide Acetate (Sandostatin) 是一种长期有效的合成生长抑素八肽类似物，可抑制生长激素的分泌。
TP2045	CH 275
	Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens
TP2052L	CTOP acetate	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	CTOP acetate 是一种生长抑素类似物和μ-阿片受体拮抗剂。
T28743	Seglitide acetate MK 678,MK678,MK-678	Somatostatin	GPCR/G Protein
	Seglitide acetate (MK-678) 是一种选择性的 sst2生长抑素受体激动剂。
TP1346	CYN 154806 TFA CYN 154806 TFA	Somatostatin	GPCR/G Protein
	CYN 154806 TFA(183658-72-2 free base) 是一种环状八肽，是一种有效的选择性生长抑素 sst2 受体拮抗剂。对于重组 sst2、sst1、sst3、sst4 和 sst5 受体，pIC50 值分别为 8.58、5.41、6.07、5.76 和 6.48。
T27787L	L-797,591 hydrochloride L-797,591 hydrochloride(217480-24-5 Free base)
	L-797,591 hydrochloride 对生长抑素受体亚型 1 (SSTR1)有活性。L-797,591 hydrochloride 常与 AG1478 联合使用来增强表达 SSTR1的细胞中 p-ERK5的表达。L-797,591 hydrochloride 在共转染的细胞中显著增强了 p38的磷酸化，这一作用在与 AG1478联合处理时被逆转。
TP2050L	CTAP(TFA） (103429-32-9 free base) CTAP(TFA）	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	CTAP(TFA) (103429-32-9 free base) 是一种有效的、高度选择性的、脑渗透性 μ-阿片受体拮抗剂，IC50 为 3.5 nM。它的选择性比 δ 阿片类药物 (IC50=4500 nM) 和生长抑素受体高 1200 倍以上。 CTAP TFA 可用于研究 L-DOPA 诱导的运动障碍 (LID)
T23073	NNC 26-9100	Others	Others
	Somatostatin sst4 receptor agonist
T24860	TC-G1003 TC G1003
	TC-G1003 is an effective agonist of the somatostatin sst2 receptor.
T28220	NVP ACQ090 NVP-ACQ090,ACQ090,ACQ 090,NVPACQ090,ACQ-090
	NVP ACQ090 is a potent and subtype-selective somatostatin sst(3) receptor antagonist.
T69836	Paltusotine HCl
	Paltusotine, also known as CRN00808, is a somatostatin receptor agonist.
TP1810	Somatostatin-25
	Somatostatin is an endogenous neuropeptide hormone found in the brain and pancreas. Somatostatin binds several isoforms of the somatostatin receptor, exhibiting anxiolytic, antiepileptic/anticonvulsant, and anorexigenic activities.
T27783	L-779976 L-779,976,L779,976,L779976,L 779976,L 779,976
	L-779,976 is an agonist of somatostatin receptor.
T22487	(1R,1'S,3'R/1R,1'R,3'S)-L-054,264	Others	Others
	somatostatin sst2 receptor agonist
T31606	EE 581 EE581,EE-581
	EE 581 can be used to label the somatostatin receptor.
T34592	Sdz 215-811 Sdz-215-811,Pentatreotide,Sdz215-811,Octreoscan 111
	Sdz 215-811 is a potential radiopharmaceutical used in somatostatin receptor-positive tumors imaging.
T22907	L-817,818	Others	Others
	somatostatin sst5 receptor agonist
T27787	L-797,591
	L-797,591 is a selective agonist of somatostatin receptor subtype 1.
T28298	Pasireotide diaspartate SOM-230,SOM230,trade name: Signifor,SOM 230,Signifor LAR
	Pasireotide is a somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs.
T16469	Pentetreotide	Others	Others
	Pentetreotide is an indium-labeled somatostatin analog and can be used for nuclear medicine imaging. Pentetreotide is a diethylenetriaminopentaacetic conjugate of Octreotide. Somatostatin receptor scintigraphy with Pentetreotide is effective in visualizin
T27761	L-054,522 L054,522
	L-054,522 is potent, selective agonists of somatostatin receptor.
T13022	SSTR5 antagonist 2	Others	Others
	SSTR5 antagonist 2 is a highly potent, oral active and selective antagonist of somatostatin (receptor) subtype 5 (SSTR5),with potential to treat type 2 diabetes mellitus (T2DM).
T13306L2	Vapreotide diacetate
	Vapreotide diacetate is a synthetic analog of somatostatin. It has analgesic activity most likely mediated through the blockade of the neurokinin-1 receptor (NK1R), the substance P (SP)-preferring receptor.
T76596	PRL 3195
	PRL 3195 是一种somatostatin receptor 拮抗剂，对人生长抑素受体 sst5、sst2、sst3、sst1和 sst4的Ki 分别为 6、17、66、1000 和 1000 nM。
T26225	SRA880 malonate SRA880,NVPSRA880,NVP-SRA880,NVP-SRA-880,NVP-SRA 880,NVP SRA880
	SRA880 is a non-peptide somatostatin sst(1) receptor antagonist which displays a significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d)= 6.0) or a wide range of neurotransmitter receptors, except for the human dopamine
T13022L	SSTR5 antagonist 2 TFA	Others	Others
	SSTR5 antagonist 2 TFA is a highly potent, oral active and selective antagonist of somatostatin (receptor) subtype 5 (SSTR5), with potential to treat type 2 diabetes mellitus (T2DM).
T28851	SRA880 free base SRA 880,NVPSRA880,NVP SRA880,NVP-SRA880,SRA-880,SRA880
	SRA880 is a non-peptide antagonist of somatostatin sst1-receptor. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0). SRA880 shows a certain binding affinity to the human dopamine D4 re
T13005	SSTR5 antagonist 1	Others	Others
	SSTR5 antagonist 1 is a selective, and orally available antagonist of somatostatin receptor subtype 5 (SSTR5)(IC50s of 9.6 and 57 nM for hSSTR5 and mSSTR5, respectively).
TP2124	Somatostatin 1-28
	Somatostatin receptor agonist, derived from the post-translational cleavage of prosomatostatin.
T39207	L-803087 TFA
	L-803087 TFA is a highly potent and selective agonist of the somatostatin sst4 receptor, exhibiting a Ki value of 0.7 nM. It displays a remarkable selectivity, being over 280-fold more preferential for the sst4 receptor compared to other somatostatin receptors. Furthermore, L-803087 TFA promotes AMPA-mediated synaptic responses in hippocampal preparations and enhances kainate-induced seizures in mice.
T75842	Cyclosomatostatin TFA
	Cyclosomatostatin TFA 作为一种有效的生长抑素(SST)受体拮抗剂，在直肠癌(CRC)细胞中通过抑制1型生长抑素受体(SSTR1)的信号传导，有效降低结细胞增殖、ALDH+细胞群体的大小以及球形成。
T76544	Cyclic SSTR agonist octreotide
	Cyclic SSTR agonist octreotide 是一种 Octreotide ，可作为生长抑素受体 (SSTR) 的激动剂。
TP2050	CTAP
	Potent and selective μ opioid receptor antagonist (IC50 = 3.5 nM). Displays > 1200-fold selectivity over δ opioid and somatostatin receptors. Brain penetrant and active in vivo.
TP1877	CYN 154806
	CYN 154806 is a potent and selective somatostatin sst2 receptor antagonist, The pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
TP2420	Veldoreotide DG 3173,DG3173,PTR 3173,DG-3173,Somatoprim
	Veldoreotide, also known as Somatoprim, is a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue which effectively reduces GH secretion in human GH-secreting pituitary adenomas, even in Octreotide non-responsive tumours.
T32511L	L-796,778 acetate L-796,778 acetate(217480-25-6 Free base)	Somatostatin	GPCR/G Protein
	L-796,778 acetate 是一种选择性生长抑素受体激动剂，对 sst3的IC50为24nM，对sst1、sst2、sst4和sst5的IC50大于1000nM。
TP1804	PEN-221
	PEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM. PEN-221 is a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate.
T11700	J-2156	Others	Others
	The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively. J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC5
T76594	PRL 2915
	PRL 2915 是一种有效的人类生长抑素亚型 2 受体拮抗剂 (hsst2)，其Ki 为 12 nM。
T75248	Pasireotide (diaspartate)
	Pasireotide (SOM230) diaspartate 是一种长效的环己肽生长激素抑制素类似物，可以提高生长抑素受体的激动剂活性，对sst1/2/3/4/5的pKi 分别为 8.2/9.0/9.1/<7.0/9.9。Pasireotide diaspartate 具有抗分泌、抗增殖和促凋亡活性。
T82883	BIM-23027
	BIM-23027为高选择性sst2受体激动剂（EC50=0.32 nM），其功能效果类似生长抑素（SRIF，环状十四肽）。该化合物可促进多巴胺的释放，此过程通过Glu依赖的机制进行调控。
T80157	DOTA-JR11
	DOTA-JR11为SSTR2生长抑素受体拮抗剂，能经68Ga标记，应用于神经内分泌肿瘤（NETs）配对成像研究。
T75917	CTAP TFA
	CTAP TFA 是一种强效、高选择性的、可透过血脑屏障的阿片受体 (μopioid receptor) 拮抗剂，IC50为 3.5 nM。CTAP TFA 对δ opioid 受体 (IC50=4500 nM) 和生长抑素受体 (somatostatin receptors) 具有超过 1200 倍的选择性。CTAP TFA 可用于L -多巴胺诱导的运动障碍 (LID) 和阿片类活性分子过量或成瘾的研究。
T60784	SSTR4 agonist 2
	SSTR4 agonist 2 是有效的生长抑素受体亚型 4 (SSTR4) 激动剂，在 SSTR4 相关的医学疾病研究中具有潜力。SSTR4 通路抑制痛觉和炎症。
T76331	Cortistatin 29
	Cortistatin 29，一种具备高亲和力结合至所有生长抑素(SS)受体亚型的神经肽，其对SSTR1、SSTR2、SSTR3、SSTR4、SSTR5的IC50值分别为2.8, 7.1, 0.2, 3.0, 13.7 nM。该化合物不仅能减轻神经性疼痛，还表现出抗纤维化作用。
T81571	PACAP (1-38) free acid TFA
	PACAP (1-38) free acid TFA，一种内源性神经肽，能有效促进胃窦运动，增强体液蛋白分泌，同时抑制胃泌素释放。此外，它刺激血管活性肠肽、胃泌素释放肽和P物质的释放，并通过RACK1增强N-甲基-D-天门冬氨酸受体功能及脑源性神经营养因子表达。
T76980	Tidutamab
	Tidutamab (XmAb-18087) 是一种具有完整 Fc 结构域的人源化及亲和优化双特异性抗体(bsAb)，旨在通过SSTR2和CD3两个靶点特异性结合来延长血清半衰期，通过激活T细胞介导的细胞毒性(RTcC)机制，有效消除SSTR+肿瘤细胞。

化合物

Cat.No: T2584

Synonym: SMS 201-995,奥曲肽

Target: Somatostatin

Pasireotide Acetate

Cat.No: TP2207

Target: Somatostatin

Cat.No: T9692

Target: Somatostatin

Octreotide Acetate

Cat.No: T4119

Synonym: 醋酸奥曲肽,SMS 201995,Longastatin,Sandostatin,SMS 201-995 (acetate)

Target: Somatostatin

Cat.No: TP2045

Cat.No: TP2052L

Target: Opioid Receptor

Seglitide acetate

Cat.No: T28743

Synonym: MK 678,MK678,MK-678

Target: Somatostatin

Cat.No: TP1346

Synonym: CYN 154806 TFA

Target: Somatostatin

L-797,591 hydrochloride

Cat.No: T27787L

Synonym: L-797,591 hydrochloride(217480-24-5 Free base)

CTAP(TFA） (103429-32-9 free base)

Cat.No: TP2050L

Synonym: CTAP(TFA）

Target: Opioid Receptor

Cat.No: T23073

Target: Others

Cat.No: T24860

Synonym: TC G1003

Cat.No: T28220

Synonym: NVP-ACQ090,ACQ090,ACQ 090,NVPACQ090,ACQ-090

Paltusotine HCl

Cat.No: T69836

Somatostatin-25

Cat.No: TP1810

Cat.No: T27783

Synonym: L-779,976,L779,976,L779976,L 779976,L 779,976

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264

Cat.No: T22487

Target: Others

Cat.No: T31606

Synonym: EE581,EE-581

Cat.No: T34592

Synonym: Sdz-215-811,Pentatreotide,Sdz215-811,Octreoscan 111

Cat.No: T22907

Target: Others

Cat.No: T27787

Pasireotide diaspartate

Cat.No: T28298

Synonym: SOM-230,SOM230,trade name: Signifor,SOM 230,Signifor LAR

Cat.No: T16469

Target: Others

Cat.No: T27761

Synonym: L054,522

SSTR5 antagonist 2

Cat.No: T13022

Target: Others

Vapreotide diacetate

Cat.No: T13306L2

Cat.No: T76596

SRA880 malonate

Cat.No: T26225

Synonym: SRA880,NVPSRA880,NVP-SRA880,NVP-SRA-880,NVP-SRA 880,NVP SRA880

SSTR5 antagonist 2 TFA

Cat.No: T13022L

Target: Others

SRA880 free base

Cat.No: T28851

Synonym: SRA 880,NVPSRA880,NVP SRA880,NVP-SRA880,SRA-880,SRA880

SSTR5 antagonist 1

Cat.No: T13005

Target: Others

Somatostatin 1-28

Cat.No: TP2124

Cat.No: T39207

Cyclosomatostatin TFA

Cat.No: T75842

Cyclic SSTR agonist octreotide

Cat.No: T76544

Cat.No: TP2050

Cat.No: TP1877

Cat.No: TP2420

Synonym: DG 3173,DG3173,PTR 3173,DG-3173,Somatoprim

L-796,778 acetate

Cat.No: T32511L

Synonym: L-796,778 acetate(217480-25-6 Free base)

Target: Somatostatin

Cat.No: TP1804

Cat.No: T11700

Target: Others

Cat.No: T76594

Pasireotide (diaspartate)

Cat.No: T75248

Cat.No: T82883

Cat.No: T80157

Cat.No: T75917

SSTR4 agonist 2

Cat.No: T60784

Cat.No: T76331

PACAP (1-38) free acid TFA

Cat.No: T81571

Cat.No: T76980

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